In cancer, information derived from tumors can serve as a useful source in delineating the tumor behavior and the role of germline variants in tumor progression. However, information from the somatic genome is largely underutilized in the assessment of the constitutional genome. The segregation of these two interdependent types of information is a bottleneck in precision oncology and genomics. INT²GRATE (INTegrated INTerpretation of GeRmline And Tumor gEnomes) Oncology is a novel multi-institutional initiative to address this limitation.

RATIONALE

VISION

To be the innovative leader in oncology in advancing precision oncology and patient care by integrating the applications of constitutional and tumor-derived data in cancer.

MISSION

• Develop Variant Evidence Framework (VEF) for cancer syndromes

• Collect and integrate large-scale tumor-derived and clinical genetics information for a comprehensive assessment of germline variants in cancer.

• Enhance genomic equity by sharing integrated variant information in publicly accessible repositories.

• Accelerate scientific solutions by creating integrated knowledge bases.

INT²GRATE Programs

INT²GRATE | ONCOLOGY

INT²GRATE | THERAPY

DATA SHARING